Mycobacterium tuberculosis: immune response, biomarkers, and therapeutic intervention.

ABSTRACT: Although tuberculosis (TB) is an infectious disease, the progression of the disease following Mycobacterium tuberculosis (MTB) infection is closely associated with the host's immune response. In this review, a comprehensive analysis of TB prevention, diagnosis, and treatment was conducted from an immunological perspective. First, we delved into the host's immune response mechanisms against MTB infection as well as the immune evasion mechanisms of the bacteria. Addressing the challenges currently faced in TB diagnosis and treatment, we also emphasized the importance of protein, genetic, and immunological biomarkers, aiming to provide new insights for early and personalized diagnosis and treatment of TB. Building upon this foundation, we further discussed intervention strategies invol

SUBMITTER: Zhuang L 

PROVIDER: S-EPMC10771061 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature