MRLC controls apoptotic cell death and functions to regulate epidermal development during planarian regeneration and homeostasis.

ABSTRACT: Adult stem cells (ASCs) are pluripotent cells with the capacity to self-renew and constantly replace lost cells due to physiological turnover or injury. Understanding the molecular mechanisms of the precise coordination of stem cell proliferation and proper cell fate decision is important to regeneration and organismal homeostasis. The planarian epidermis provides a highly tractable model to study ASC complex dynamic due to the distinct spatiotemporal differentiation stages during lineage development. Here, we identified the myosin regulatory light chain (MRLC) homologue in the Dugesia japonica transcriptome. We found high expression levels of MRLC in wound region during regeneration and also expressed in late epidermal progenitors as an essential regulator of the lineage from neoblasts to

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10771114 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature