Lymphatic venous anastomosis and complex decongestive therapy for lymphoedema: randomized clinical trial.

ABSTRACT:

Background

Lymphatic venous anastomosis is associated with a low incidence of lower extremity lymphoedema-associated cellulitis; however, the exact relationship is unknown. This multicentre RCT evaluated the effect of lymphatic venous anastomosis on prevention of cellulitis.

Methods

Patients with secondary lower extremity lymphoedema who underwent at least 3 months of non-operative decongestive therapy were assigned randomly to lymphatic venous anastomosis or conservative therapy. The primary and secondary outcomes were cellulitis frequency, and assessments of circumference, hardness, and pain respectively.

Results

Overall, 336 patients were divided into two groups: 225 in the full-analysis set (primary outcome 225; secondary outcomes 170) and 156 in the per-protocol

SUBMITTER: Mihara M 

PROVIDER: S-EPMC10771256 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature