Diffusion MRI correlation with p16 status and prediction for tumor progression in locally advanced head and neck cancer.

ABSTRACT:

Purpose

To investigate p16 effects on diffusion image metrics and associations with tumor progression in patients with locally advanced head and neck cancers.

Methods

Diffusion images pretreatment and after 20 Gy (2wk) of RT were analyzed in patients with cT4/N3 p16+ oropharynx cancer (OPSCC) (N=51) and locoregionally advanced head and neck squamous cell carcinoma (LAHNSCC) (N=28), enrolled onto a prospective adaptive RT trial. Mean ADC values, subvolumes with ADC <1.2 um²/ms (TV_LADC), and peak values of low (µ_L) and high (µ_H) components of ADC histograms in primary and total nodal gross tumor volumes were analyzed for prediction of freedom from local, distant, or any progression (FFLP, FFDP or FFLRDP) using multivariate Cox propor

SUBMITTER: Cao Y 

PROVIDER: S-EPMC10771284 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature