Two-sample Mendelian randomization study reveals no causal relationship between inflammatory bowel disease and urological cancers.

ABSTRACT: Background: The relationship between inflammatory bowel disease (IBD) and urological cancers has been identified in epidemiological and observational studies, while the causality remains uncertain. We examined whether IBD is causally associated with urological cancers in a Mendelian randomization (MR) study. Methods: The causal relationship between IBD, its main subtypes, and urological cancers was investigated using genome-wide association study data. To obtain more reliable conclusions, all outcomes were divided into training and validation sets. Eligible single-nucleotide polymorphisms were selected as instrumental variables based on MR analysis assumptions. The inverse variance-weighted (IVW) method was employed as the main method along with four other complementary metho

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10771298 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature