Cu(II)-Mediated direct ¹⁸F-dehydrofluorination of phosphine oxides in high molar activity.

ABSTRACT:

Background

The ¹⁸F/¹⁹F-isotope exchange method employing P(V)-centered prosthetic groups demonstrates advantages in addressing mild one-step aqueous ¹⁸F-labeling of peptides and proteins. However, the molar activity (A_m) achieved through isotope exchange remains relatively low, unless employing a high initial activity of [¹⁸F]F^-. To overcome this drawback, our work introduces a novel approach through a Cu-mediated direct ¹⁸F-dehydrofluorination of phosphine oxides. This method leverages the straightforward separation of the ¹⁸F-labeled product from the phosphine oxide precursors, aiming to primarily increase A_m.

Results

Through a ¹⁹F-dehydrofluorination efficiency te

SUBMITTER: Tang X 

PROVIDER: S-EPMC10771395 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature