Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation.

ABSTRACT: Mammary gland development occurs primarily in adulthood, undergoing extensive expansion during puberty followed by cycles of functional specialization and regression with every round of pregnancy/lactation/involution. This process is ultimately driven by the coordinated proliferation and differentiation of mammary epithelial cells. However, the endogenous molecular factors regulating these developmental dynamics are still poorly defined. Endocannabinoid signaling is known to determine cell fate-related events during the development of different organs in the central nervous system and the periphery. Here, we report that the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) plays a pivotal role in adult mammary gland development. Specifically, it is required for luminal lin

SUBMITTER: Tundidor I 

PROVIDER: S-EPMC10771414 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature