Domestic pigs are susceptible to experimental infection with non-human primate-derived Reston virus without the need for adaptation.

ABSTRACT: Domestic pigs are a critical component of the food supply and one of the most commonly raised production animals. Pork consumption has driven the intensification of pig production expanding into environments conducive to increased emergence and spread of infectious diseases, including the spillover of pathogens into human populations. One of these emerging viruses, Reston virus (RESTV), is an enigma among the Orthoebolavirus genus in that its lack of human pathogenicity is in stark contrast to the high virulence associated with most other ebolaviruses. RESTV is, however, associated with outbreaks of highly lethal hemorrhagic disease in non-human primates (NHP), as well as poorly understood clinical manifestations of mixed virulence and lethality in naturally and experimentally infected dom

SUBMITTER: Lewis CE 

PROVIDER: S-EPMC10771446 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature