ARCTIC-3D: automatic retrieval and clustering of interfaces in complexes from 3D structural information.

ABSTRACT: The formation of a stable complex between proteins lies at the core of a wide variety of biological processes and has been the focus of countless experiments. The huge amount of information contained in the protein structural interactome in the Protein Data Bank can now be used to characterise and classify the existing biological interfaces. We here introduce ARCTIC-3D, a fast and user-friendly data mining and clustering software to retrieve data and rationalise the interface information associated with the protein input data. We demonstrate its use by various examples ranging from showing the increased interaction complexity of eukaryotic proteins, 20% of which on average have more than 3 different interfaces compared to only 10% for prokaryotes, to associating different functions to diff

SUBMITTER: Giulini M 

PROVIDER: S-EPMC10771469 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature