Constructing a finer-grained representation of clinical trial results from ClinicalTrials.gov.

ABSTRACT: Randomized controlled trials are essential for evaluating clinical interventions; however, selective reporting and publication bias in medical journals have undermined the integrity of the clinical evidence system. ClinicalTrials.gov serves as a valuable and complementary repository, yet synthesizing information from it remains challenging. This study introduces a curated dataset that extends beyond the traditional PICO framework. It links efficacy with safety results at the experimental arm group level within each trial, and connects them across all trials through a knowledge graph. This novel representation effectively bridges the gap between generally described searchable information and specifically detailed yet underutilized reported results, and promotes a dual-faceted understanding

SUBMITTER: Shi X 

PROVIDER: S-EPMC10771511 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature