Associations of genetic variants contributing to gut microbiota composition in diabetic nephropathy.

ABSTRACT:

Introduction

The gut microbiota is strongly associated with multiple kidney diseases, and since microbial composition is heritable, we hypothesized that genetic variations controlling gut microbiota composition were associated with diabetic nephropathy susceptibility or clinical subphenotypes.

Methods

The genetic variations associated with gut microbiota were retrieved from the genome-wide association study database and analysed in our diabetic nephropathy susceptibility gene screening cohort. Candidate microorganisms with possible genetic associations were identified using the annotation of microbial quantitative trait loci. Finally, the candidate microorganisms were verified by 16S rDNA gene sequencing.

Results

There were 13 genetic variation loci associated with su

SUBMITTER: Lu X 

PROVIDER: S-EPMC10771622 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature