Tenecteplase for the treatment of acute ischemic stroke in the extended time window: a systematic review and meta-analysis.

ABSTRACT:

Background

Outcome data regarding the administration of tenecteplase (TNK) to acute ischemic stroke (AIS) patients presenting in the extended time window are limited.

Objectives

We aimed to assess the current evidence regarding the efficacy and safety of TNK at a dose of 0.25 mg/kg for AIS treatment in the extended time window.

Design

A systematic review and meta-analysis was conducted including all available randomized-controlled clinical trials (RCTs) that compared TNK 0.25 mg/kg versus no thrombolysis in AIS patients presenting in the extended time window (>4.5 h after last-seen-well or witnessed onset).

Data sources and methods

Eligible studies were identified by searching Medline, Scopus, and international conference abstracts. The predefined effica

SUBMITTER: Palaiodimou L 

PROVIDER: S-EPMC10771742 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature