High CTLA-4 transcriptomic expression correlates with high expression of other checkpoints and with immunotherapy outcome.

ABSTRACT:

Background

CTLA-4 impedes the immune system's antitumor response. There are two Food and Drug Administration-approved anti-CTLA-4 agents - ipilimumab and tremelimumab - both used together with anti-PD-1/PD-L1 agents.

Objective

To assess the prognostic implications and immunologic correlates of high CTLA-4 in tumors of patients on immunotherapy and those on non-immunotherapy treatments.

Design/methods

We evaluated RNA expression levels in a clinical-grade laboratory and clinical correlates of CTLA-4 and other immune checkpoints in 514 tumors, including 489 patients with advanced/metastatic cancers and full outcome annotation. A reference population (735 tumors; 35 histologies) was used to normalize and rank transcript abundance (0-100 percentile) to internal housekeepi

SUBMITTER: Krishnamurthy N 

PROVIDER: S-EPMC10771755 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature