The expression and clinical significance of serine hydroxymethyltransferase2 in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most common malignant tumours in the digestive system. Serine hydroxymethyltransferase 2 (SHMT2) is one of the key enzymes associated with serine metabolism. However, the prognostic role of SHMT2 in GC carcinogenesis has yet to be studied.

Methods

The expression of SHMT2 in human tumors and normal tissues was detected by the Assistant for Clinical Bioinformatics and Immunohistochemistry (IHC). The relationship of the expression of SHMT2 with clinical characteristics and survival data was analysed by the chi-square test, survival analysis and online databases. Finally, the correlation between SHMT2 expression and associated signalling channels, and molecules was analysed by online databases.

Results

SHMT2 was strongly expres

SUBMITTER: Shan Y 

PROVIDER: S-EPMC10771762 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature