Gut Microbiota and Cognitive Function Among Women Living with HIV.

ABSTRACT:

Background

Altered gut microbiota has been associated with cognitive dysfunction and Alzheimer's disease, but little is known among people living with HIV.

Objective

To examine associations between gut microbiota and cognitive impairment among women with or without HIV.

Methods

This is a cross-sectional study of 446 women (302 HIV+) who had completed a neuropsychological test battery and stool sample collected within 1 year. Gut microbiota composition was quantified using 16SV4 rRNA gene sequencing and microbial functional pathways were predicted using PICRUSt. Cognitive domains included attention, executive function, learning, memory, fluency, processing speed, and motor function. Cognitive impairment was defined as two or more domains with T scores < 1 SD below mean

SUBMITTER: Hua S 

PROVIDER: S-EPMC10771810 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature