Sodium intake and the risk of various types of cardiovascular diseases: a Mendelian randomization study.

ABSTRACT:

Background

The existing literature on the link between sodium intake and cardiovascular disease (CVD) largely consists of observational studies that have yielded inconsistent conclusions. In this study, our objective is to assess the causal relationship between sodium intake and 50 CVDs using two-sample Mendelian randomization (MR) analysis.

Methods

MR analyses were performed to investigate the associations between urinary sodium/creatinine ratio (U_Na/U_Cr), an indicator of sodium intake, and 50 CVDs. The genome-wide association study (GWAS) for U_Na/U_Cr was from the UK Biobank (UKBB), and the GWASs for CVDs were from FinnGen. A false discovery rate (FDR) threshold of 5% was applied for multiple comparison correction.

Results

SUBMITTER: Fu Q 

PROVIDER: S-EPMC10771828 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature