Adaptive design clinical trials: current status by disease and trial phase in various perspectives.

ABSTRACT: An adaptive design is a clinical trial design that allows for modification of a structured plan in a clinical trial based on data accumulated during pre-planned interim analyses. This flexible approach to clinical trial design improves the success rate of clinical trials while reducing time, cost, and sample size compared to conventional methods. The purpose of this study is to identify the current status of adaptive design and present key considerations for planning an appropriate adaptive design based on specific circumstances. We searched for clinical trials conducted between January 2006 to July 2021 in the Clinical Trials Registry (ClinicalTrials.gov) using keywords specified in the Food and Drug Administration Adaptive Design Clinical Trial Guidelines. In order to analyze the adaptiv

SUBMITTER: Lee H 

PROVIDER: S-EPMC10772057 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature