Arsenic album 30C exhibits crystalline nano structure of arsenic trioxide and modulates innate immune markers in murine macrophage cell lines.

ABSTRACT: Macrophages are associated with innate immune response and M1-polarized macrophages exhibit pro-inflammatory functions. Nanoparticles of natural or synthetic compounds are potential triggers of innate immunity. As₂O₃ is the major component of the homeopathic drug, Arsenic album 30C.This has been claimed to have immune-boosting activities, however, has not been validated experimentally. Here we elucidated the underlying mechanism of Ars. alb 30C-mediated immune priming in murine macrophage cell line. Transmission Electron Microscopy (TEM) and X-ray diffraction (XRD) used for the structural analysis of the drug reveals the presence of crystalline As₂O₃ nanoparticles of cubic structure. Similarly, signatures of M1-macrophage polarization were observ

SUBMITTER: Rath S 

PROVIDER: S-EPMC10772077 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature