Protein profiling and assessment of amyloid beta levels in plasma in canine refractory epilepsy.

ABSTRACT:

Introduction

The relationship between epilepsy and cognitive dysfunction has been investigated in canines, and memory impairment was prevalent in dogs with epilepsy. Additionally, canines with epilepsy have greater amyloid-β (Aβ) accumulation and neuronal degeneration than healthy controls. The present study investigated plasma Aβ₄₂ levels and performed proteomic profiling in dogs with refractory epilepsy and healthy dogs.

Methods

In total, eight dogs, including four healthy dogs and four dogs with epilepsy, were included in the study. Blood samples were collected to analyze Aβ₄₂ levels and perform proteomic profiling. Changes in the plasma proteomic profiles of dogs were determined by nano liquid chromatography tandem mass spectrometry.

Results and

SUBMITTER: Phochantachinda S 

PROVIDER: S-EPMC10772147 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature