Combined population genomic screening for three high-risk conditions in Australia: a modelling study.

ABSTRACT:

Background

No previous health-economic evaluation has assessed the impact and cost-effectiveness of offering combined adult population genomic screening for mutliple high-risk conditions in a national public healthcare system.

Methods

This modeling study assessed the impact of offering combined genomic screening for hereditary breast and ovarian cancer, Lynch syndrome and familial hypercholesterolaemia to all young adults in Australia, compared with the current practice of clinical criteria-based testing for each condition separately. The intervention of genomic screening, assumed as an up-front single cost in the first annual model cycle, would detect pathogenic variants in seven high-risk genes. The simulated population was 18-40 year-olds (8,324,242 individuals), modellin

SUBMITTER: Lacaze P 

PROVIDER: S-EPMC10772163 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature