Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets.

ABSTRACT: Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate mechanisms underlying I/R injury hinders the development of effective therapeutic interventions. The Wnt signaling pathway exhibits extensive crosstalk with various other pathways, forming a network system of signaling pathways involved in I/R injury. This review article elucidates the underlying mechanisms involved in Wnt signaling, as well as the complex interplay between Wnt and other pathways, including Notch, phosphatidylinositol 3-kinase/protein kinase B, transforming growth factor-β, nuclear factor kappa, bone morphogenetic protein, N-methyl-D-aspartic acid receptor-Ca²⁺-Activin A, Hippo-Yes-associ

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10772178 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature