Integrative analysis of rs717620 polymorphism in therapeutic response to anti-seizure medications.

ABSTRACT:

Background

Previous studies have shown that the rs717620 polymorphism in ABCC2, the gene encoding multidrug resistance protein 2, influences the therapeutic response to anti-seizure medications (ASMs). However, this result is not consistent, and the mechanism by which rs717620 influences ASM responses is unclear.

Aims

The present study evaluated the association between rs717620 genotype and ASM efficacy, and examined the potential mechanisms.

Main

methods: We conducted a literature search of five electronic databases, Embase, Medline, Web of Science, China National Knowledge Infrastructure, and Wanfang, to identify relevant studies on response to ASM therapy among rs717620 genotypes. Expression quantitative trait loci analysis and drug-gene interaction analysis

SUBMITTER: Wang S 

PROVIDER: S-EPMC10772244 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature