MFG-E8 promotes M2 polarization of macrophages and is associated with poor prognosis in patients with gastric cancer.

ABSTRACT:

Background

Milk Fat Globule-Epidermal Growth Factor 8 (MFG-E8) has been reported to play an oncogenic role in a variety of tumors. However, its involvement in gastric cancer (GC) development has not been described.

Methods

The cancer genome atlas (TCGA) and the gene expression omnibus database (GEO) databases were used to analyze the expression of MFG-E8 in GC. These findings were further validated using immunohistochemistry (IHC) and western blotting assay (WB). Kaplan-Meier method, univariate logistic regression, and Christopher Cox regression were used to study the relationship between MFG-E8 and clinical pathology. In addition, the potential signaling pathways involved in MFG-E8 and its potential correlation with levels of immune cell infiltration were investigated. Fina

SUBMITTER: Li Y 

PROVIDER: S-EPMC10772258 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature