Generation of chimeric antigen receptor macrophages from human pluripotent stem cells to target glioblastoma.

ABSTRACT:

Background

Glioblastoma (GBM) is an aggressive brain tumor giving a poor prognosis with the current treatment options. The advent of chimeric antigen receptor (CAR) T-cell therapy revolutionized the field of immunotherapy and has provided a new set of therapeutic options for refractory blood cancers. In an effort to apply this therapeutic approach to solid tumors, various immune cell types and CAR constructs are being studied. Notably, macrophages have recently emerged as potential candidates for targeting solid tumors, attributed to their inherent tumor-infiltrating capacity and abundant presence in the tumor microenvironment.

Materials and methods

In this study, we developed a chemically defined differentiation protocol to generate macrophages from human pluripotent stem c

SUBMITTER: Jin G 

PROVIDER: S-EPMC10772262 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature