Spleen stiffness measurement predicts decompensation and rules out high-risk oesophageal varices in primary biliary cholangitis.

ABSTRACT:

Background & aims

Primary biliary cholangitis (PBC) may lead to portal hypertension (PH). Spleen stiffness measurement (SSM) by vibration-controlled transient elastography accurately predicts PH. We aimed to assess SSM role in stratifying the risk of liver decompensation in PBC.

Methods

In this monocentric, prospective, cross-sectional study, we included 114 patients with PBC who underwent liver stiffness measurement (LSM) and SSM. In total, 78 and 33 patients underwent two and three sequential vibration-controlled transient elastography examinations, respectively (longitudinal study). Screening for high-risk oesophageal varices by oesophagogastroduodenoscopy was performed according to guidelines and proposed to all patients with SSM >40 kPa.

Results

Among the 114 pat

SUBMITTER: Rigamonti C 

PROVIDER: S-EPMC10772386 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature