Efficacy of Letrozole vs Clomiphene Citrate for induction of ovulation in women with polycystic ovarian syndrome.

ABSTRACT:

Objective

To compare the efficacy of letrozole vs Clomiphene citrate for ovulation induction in PCOS women.

Methods

This double blind randomized controlled trial was conducted at Services Hospital, Lahore, from January 2016 to December 2020. Total 220 patients, diagnosed with PCOS according to Rotterdam criteria were randomly assigned into two groups after taking informed consent. The women were followed for ovulation, pregnancy and live birth rates in the next five consecutive menstrual cycles with either clomiphene citrate or letrozole.

Results

Letrozole had significantly better pregnancy rate (29.0% vs 15.4% p-value 0.015), monofollicular development (77.2% vs 52.7% p-value 0.000) and live birth rate (25.4% vs 10.9% p-value 0.005) as compared to clomiphene citrate.

SUBMITTER: Wasim T 

PROVIDER: S-EPMC10772410 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature