The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans.

ABSTRACT: The belief that the anabolic response to feeding during postexercise recovery is transient and has an upper limit and that excess amino acids are being oxidized lacks scientific proof. Using a comprehensive quadruple isotope tracer feeding-infusion approach, we show that the ingestion of 100 g protein results in a greater and more prolonged (>12 h) anabolic response when compared to the ingestion of 25 g protein. We demonstrate a dose-response increase in dietary-protein-derived plasma amino acid availability and subsequent incorporation into muscle protein. Ingestion of a large bolus of protein further increases whole-body protein net balance, mixed-muscle, myofibrillar, muscle connective, and plasma protein synthesis rates. Protein ingestion has a negligible impact on whole-body protein

SUBMITTER: Trommelen J 

PROVIDER: S-EPMC10772463 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature