Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity.

ABSTRACT: The gut microbiota contributes to the pathophysiology of non-alcoholic fatty liver disease (NAFLD). Histidine is a key energy source for the microbiota, scavenging it from the host. Its role in NAFLD is poorly known. Plasma metabolomics, liver transcriptomics, and fecal metagenomics were performed in three human cohorts coupled with hepatocyte, rodent, and Drosophila models. Machine learning analyses identified plasma histidine as being strongly inversely associated with steatosis and linked to a hepatic transcriptomic signature involved in insulin signaling, inflammation, and trace amine-associated receptor 1. Circulating histidine was inversely associated with Proteobacteria and positively with bacteria lacking the histidine utilization (Hut) system. Histidine supplementation improved NA

SUBMITTER: Quesada-Vazquez S 

PROVIDER: S-EPMC10772641 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature