Prospective observational study of zinc deficiency symptoms during first-line chemotherapy for gastric and colorectal cancer.

ABSTRACT: Zinc deficiency during long-term chemotherapy and its related symptoms, including skin rash, taste disorders, and oral mucositis, have not been sufficiently investigated. This prospective observational study enrolled patients with gastric and colorectal cancer who underwent standard first-line chemotherapy. According to the Practice Guidelines for Zinc Deficiency, zinc deficiency is defined as a serum level of <60 µg/dL. Serum zinc levels were measured before and after (1, 3, and 6 months) chemotherapy, and symptoms were assessed using the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events version 1.0. Repeated measures were analyzed using a generalized linear mixed model. Of the 61 enrolled patients, 48 who underwent standard first-line chemotherapy wi

SUBMITTER: Sakaguchi C 

PROVIDER: S-EPMC10772688 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature