Functional Evaluation of Retinal Pigment Epithelium and Outer Retinal Atrophy by High-Density Targeted Microperimetry Testing.

ABSTRACT:

Purpose

Complete retinal pigment epithelium (RPE) and outer retinal atrophy (cRORA) on OCT imaging has recently been proposed to describe end-stage atrophy in age-related macular degeneration (AMD) by international consensus and expected to be associated with a dense scotoma, but such functional evidence is lacking. This study sought to examine the visual sensitivity defects associated with cRORA and to determine OCT features associated with deep defects.

Design

Observational study.

Participants

Sixty eyes from 53 participants, including 342 microperimetry tests over 171 study visits.

Methods

Participants underwent targeted high-density threshold-based microperimetry testing of atrophic lesions (with at least incomplete RPE and outer retinal atrophy [iRO

SUBMITTER: Wu Z 

PROVIDER: S-EPMC10772812 | biostudies-literature | 2024 Mar-Apr

REPOSITORIES: biostudies-literature