Nutrient-sensing growth hormone secretagogue receptor in macrophage programming and meta-inflammation.

ABSTRACT:

Objective

Obesity-associated chronic inflammation, aka meta-inflammation, is a key pathogenic driver for obesity-associated comorbidity. Growth hormone secretagogue receptor (GHSR) is known to mediate the effects of nutrient-sensing hormone ghrelin in food intake and fat deposition. We previously reported that global Ghsr ablation protects against diet-induced inflammation and insulin resistance, but the site(s) of action and mechanism are unknown. Macrophages are key drivers of meta-inflammation. To unravel the role of GHSR in macrophages, we generated myeloid-specific Ghsr knockout mice (LysM-Cre;Ghsr^f/f).

Methods

LysM-Cre;Ghsr^f/f and control Ghsr^f/f mice were subjected to 5 months of high-fat diet (HFD) feeding to induce obesity. In vivo,

SUBMITTER: Kim DM 

PROVIDER: S-EPMC10772824 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature