Predicting the apolipoprotein E ε4 allele carrier status based on gray matter volumes and cognitive function.

ABSTRACT:

Background

Apolipoprotein E (ApoE) ε4 carriers have a higher risk of developing Alzheimer's disease (AD) and show brain atrophy and cognitive decline even before diagnosis.

Objective

To predict ApoE ε4 status using gray matter volume (GMV) obtained from magnetic resonance imaging images and demographic data with machine learning (ML) methods.

Methods

We recruited 74 participants (25 probable AD, 24 amnestic mild cognitive impairment, and 25 cognitively normal older people) with known ApoE genotype (22 ApoE ε4 carriers and 52 noncarriers) and scanned them with three-dimensional (3D) T1-weighted (T1W) and 3D double inversion recovery (DIR) sequences. We extracted GMV from regions of interest related to AD pathology and used them as features along with age and mini-menta

SUBMITTER: Kim HG 

PROVIDER: S-EPMC10772845 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature