D-dimer predicts venous thromboembolism in multiple myeloma: a nested case-control study.

ABSTRACT:

Background

Clinical risk assessment scores, such as IMPEDE VTE, can identify patients with multiple myeloma (MM) at high-risk of venous thromboembolism (VTE). Refinement of these scores, by including 1 or more biomarkers, could improve risk assessment.

Objectives

We sought to determine the association between soluble P-selectin (sP-selectin) and D-dimer with VTE in MM.

Methods

We identified 545 patients with newly diagnosed MM. Using a nested case-control design, we identified 38 cases of VTE within 6-months of MM treatment and 137 randomly selected controls. Using logistic regression, we examined the association between D-dimer and sP-selectin with VTE. We also analyzed the association after adjusting for IMPEDE VTE.

Results

Each 1-point increase in IMPEDE VTE

SUBMITTER: Sanfilippo KM 

PROVIDER: S-EPMC10772878 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature