Asthma exacerbations and eosinophilia in the UK Biobank: a genome-wide association study.

ABSTRACT:

Background

Asthma exacerbations reflect disease severity, affect morbidity and mortality, and may lead to declining lung function. Inflammatory endotypes (e.g. T2-high (eosinophilic)) may play a key role in asthma exacerbations. We aimed to assess whether genetic susceptibility underlies asthma exacerbation risk and additionally tested for an interaction between genetic variants and eosinophilia on exacerbation risk.

Methods

UK Biobank data were used to perform a genome-wide association study of individuals with asthma and at least one exacerbation compared to individuals with asthma and no history of exacerbations. Individuals with asthma were identified using self-reported data, hospitalisation data and general practitioner records. Exacerbations were identified as

SUBMITTER: Edris A 

PROVIDER: S-EPMC10772900 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature