Development of innovative multi-epitope mRNA vaccine against Pseudomonas aeruginosa using in silico approaches.

ABSTRACT: The rising issue of antibiotic resistance has made treating Pseudomonas aeruginosa infections increasingly challenging. Therefore, vaccines have emerged as a viable alternative to antibiotics for preventing P. aeruginosa infections in susceptible individuals. With its superior accuracy, high efficiency in stimulating cellular and humoral immune responses, and low cost, mRNA vaccine technology is quickly replacing traditional methods. This study aimed to design a novel mRNA vaccine by using in silico approaches against P. aeruginosa. The research team identified five surface and antigenic proteins and selected their appropriate epitopes with immunoinformatic tools. These epitopes were then examined for toxicity, allergenicity and homology. The researchers also checked their presentation and

SUBMITTER: Asadinezhad M 

PROVIDER: S-EPMC10772946 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature