Synthesis of carbon dot based Schiff bases and selective anticancer activity in glioma cells.

ABSTRACT: Schiff bases have remarkable anticancer activity and are used for glioma therapy. However, the poor water solubility/dispersibility limits their therapeutic potential in biological systems. To address this issue, carbon dots (CDs) have been utilized to enhance the dispersibility in water and biological efficacy of Schiff bases. The amino groups on the surface of CDs were conjugated effectively with the aldehyde group of terephthalaldehyde to form novel CD-based Schiff bases (CDSBs). The results of the MTT assays demonstrate that CDSBs have significant anticancer activity in glioma GL261 cells and U251 cells, with IC50 values of 17.9 μg mL^-1 and 14.9 μg mL^-1, respectively. CDSBs have also been found to have good biocompatibility with normal glial cells. The production

SUBMITTER: Zhuang Y 

PROVIDER: S-EPMC10772990 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature