Ovarian cancer cells regulate their mitochondrial content and high mitochondrial content is associated with a poor prognosis.

ABSTRACT: Most cancer patients ultimately die from the consequences of distant metastases. As metastasis formation consumes energy mitochondria play an important role during this process as they are the most important cellular organelle to synthesise the energy rich substrate ATP, which provides the necessary energy to enable distant metastasis formation. However, mitochondria are also important for the execution of apoptosis, a process which limits metastasis formation. We therefore wanted to investigate the mitochondrial content in ovarian cancer cells and link its presence to the patient's prognosis in order to analyse which of the two opposing functions of mitochondria dominates during the malignant progression of ovarian cancer. Monoclonal antibodies directed against different mitochondrial spe

SUBMITTER: Weigelt J 

PROVIDER: S-EPMC10773013 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature