Metformin and adipose-derived stem cell combination therapy alleviates radiation-induced skin fibrosis in mice.

ABSTRACT:

Background

Radiation therapy often leads to late radiation-induced skin fibrosis (RISF), causing movement impairment and discomfort. We conducted a comprehensive study to assess the effectiveness of metformin and adipose-derived stem cells (ASCs), whether autologous or allogeneic, individually or in combination therapy, in mitigating RISF.

Methods

Using a female C57BL/6J mouse model subjected to hind limb irradiation as a representative RISF model, we evaluated metformin, ASCs, or their combination in two contexts: prophylactic (started on day 1 post-irradiation) and therapeutic (initiated on day 14 post-irradiation, coinciding with fibrosis symptoms). We measured limb movement, examined skin histology, and analyzed gene expression to assess treatment efficacy.

Results

SUBMITTER: Malekzadeh H 

PROVIDER: S-EPMC10773046 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature