Lipid changes during endocrine therapy in early-stage breast cancer patients: A real-world study.

ABSTRACT:

Background

Endocrine drugs may affect lipid metabolism in breast cancer (BC) patients. This study explores lipid changes in early-stage BC patients taking different endocrine drugs.

Methods

The changing trend of blood lipid during endocrine therapy in 2756 BC patients from January 2013 to December 2021 was retrospectively analyzed. The changes in four lipid parameters were assessed by the Generalized Linear Mixed Model, including total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C). These parameters were quantified at baseline and at 6, 12, 18, 24, 36, 48, 60, and 72 months after endocrine therapy initiation. Furthermore, a subgroup analysis according to menopausal status or medication types was conducted.

Resul

SUBMITTER: Li Y 

PROVIDER: S-EPMC10773127 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature