Long-read transcriptome landscapes of primary and metastatic liver cancers at transcript resolution.

ABSTRACT:

Background

The liver ranks as the sixth most prevalent site of primary cancer in humans, and it frequently experiences metastases from cancers originating in other organs. To facilitate the development of effective treatments and improve survival rates, it is crucial to comprehend the intricate and diverse transcriptome landscape of primary and metastatic liver cancers.

Methods

We conducted long-read isoform sequencing and short-read RNA sequencing using a cohort of 95 patients with primary and secondary liver cancer who underwent hepatic resection. We compared the transcriptome landscapes of primary and metastatic liver cancers and systematically investigated hepatocellular carcinoma (HCC), paired primary tumours and liver metastases, and matched nontumour liver tissues.

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10773130 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature