In-depth metaproteomics analysis of tongue coating for gastric cancer: a multicenter diagnostic research study.

ABSTRACT:

Background

Our previous study revealed marked differences in tongue images between individuals with gastric cancer and those without gastric cancer. However, the biological mechanism of tongue images as a disease indicator remains unclear. Tongue coating, a major factor in tongue appearance, is the visible layer on the tongue dorsum that provides a vital environment for oral microorganisms. While oral microorganisms are associated with gastric and intestinal diseases, the comprehensive function profiles of oral microbiota remain incompletely understood. Metaproteomics has unique strength in revealing functional profiles of microbiota that aid in comprehending the mechanism behind specific tongue coating formation and its role as an indicator of gastric cancer.

Methods

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SUBMITTER: Chen J 

PROVIDER: S-EPMC10773145 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature