Secreted IgM modulates IL-10 expression in B cells.

ABSTRACT: IL-10⁺ B cells are critical for immune homeostasis and restraining immune responses in infection, cancer, and inflammation; however, the signals that govern IL-10⁺ B cell differentiation are ill-defined. Here we find that IL-10⁺ B cells expand in mice lacking secreted IgM ((s)IgM^-/-) up to 10-fold relative to wildtype (WT) among all major B cell and regulatory B cell subsets. The IL-10⁺ B cell increase is polyclonal and presents within 24 hours of birth. In WT mice, sIgM is produced prenatally and limits the expansion of IL-10⁺ B cells. Lack of the high affinity receptor for sIgM, FcμR, in B cells translates into an intermediate IL-10⁺ B cell phenotype relative to WT or sIgM^-/- mice. Our study thus show

SUBMITTER: McGettigan SE 

PROVIDER: S-EPMC10773282 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature