A Mendelian randomization study: physical activities and chronic kidney disease.

ABSTRACT: Increasing evidence has shown that physical activity is related to a lower risk of chronic kidney disease (CKD), thus indicating a potential target for prevention. However, the causality is not clear; specifically, physical activity may protect against CKD, and CKD may lead to a reduction in physical activity. Our study examined the potential bidirectional relationship between physical activity and CKD by using a genetically informed method. Genome-wide association studies from the UK Biobank baseline data were used for physical activity phenotypes and included 460,376 participants. For kidney function (estimated Glomerular Filtration Rate (eGFR) and CKD, with eGFR < 60 mL/min/1.73 m²), CKDGen Consortium data were used, which included 480,698 CKD participants of European ancestr

SUBMITTER: Xiao R 

PROVIDER: S-EPMC10773648 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature