First report of Candida auris in Guangdong, China: clinical and microbiological characteristics of 7 episodes of candidemia.

ABSTRACT: Candida auris is an emerging multidrug-resistant fungal pathogen worldwide. To date, it has not been reported in Guangdong, China. For the first time, we reported 7 cases of C. auris candidemia from two hospitals in Guangdong. The clinical and microbiological characteristics of these cases were investigated carefully. Two geographic clades, i.e. III and I, were found popular in different hospitals by whole genome sequencing analyses. All C. auris isolates from bloodstream were resistant to fluconazole, 5 of which belonged to Clade III harbouring VF125AL mutation in the ERG11 gene. The isolates with Clade I presented Y132F mutation in the ERG11 gene as well as resistance to amphotericin B. All isolates exhibited strong biofilm-forming capacity and non-aggr

SUBMITTER: Peng Y 

PROVIDER: S-EPMC10773663 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature