The first exome wide association study in Tunisia: identification of candidate loci and pathways with biological relevance for type 2 diabetes.

ABSTRACT:

Introduction

Type 2 diabetes (T2D) is a multifactorial disease involving genetic and environmental components. Several genome-wide association studies (GWAS) have been conducted to decipher potential genetic aberrations promoting the onset of this metabolic disorder. These GWAS have identified over 400 associated variants, mostly in the intronic or intergenic regions. Recently, a growing number of exome genotyping or exome sequencing experiments have identified coding variants associated with T2D. Such studies were mainly conducted in European populations, and the few candidate-gene replication studies in North African populations revealed inconsistent results. In the present study, we aimed to discover the coding genetic etiology of T2D in the Tunisian population.

Methods

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SUBMITTER: Dallali H 

PROVIDER: S-EPMC10773763 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature