Specific gut microbiota may increase the risk of erectile dysfunction: a two-sample Mendelian randomization study.

ABSTRACT:

Objective

Studies have found that gut microbiota may be associated with the development of erectile dysfunction (ED); however, the exact link between the two remains unclear. This study aimed to elucidate the relationship between the gut microbiota and the risk of ED from a genetic perspective.

Methods

We investigated the relationship between the gut microflora and ED using two-sample Mendelian randomization. GWAS-pooled data for ED were obtained from 223805 participants in Europe. GWAS summary data for ED were obtained from 223805 subjects in Europe and that for the gut microbiota were obtained from 18340 participants in 24 cohorts. We used the inverse-variance weighted (IVW) estimator as the primary method for the preliminary analysis, and the MR-Egger, weighted median (WM

SUBMITTER: Su Q 

PROVIDER: S-EPMC10773840 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature