Effect of stretching on inflammation in a subcutaneous carrageenan mouse model analyzed at single-cell resolution.

ABSTRACT: Understanding the factors that influence the biological response to inflammation is crucial, due to its involvement in physiological and pathological processes, including tissue repair/healing, cancer, infections, and autoimmune diseases. We have previously demonstrated that in vivo stretching can reduce inflammation and increase local pro-resolving lipid mediators in rats, suggesting a direct mechanical effect on inflammation resolution. Here we aimed to explore further the effects of stretching at the cellular/molecular level in a mouse subcutaneous carrageenan-inflammation model. Stretching for 10 min twice a day reduced inflammation, increased the production of pro-resolving mediator pathway intermediate 17-HDHA at 48 h postcarrageenan injection, and decreased both pro-resolving and pr

SUBMITTER: Berrueta L 

PROVIDER: S-EPMC10773986 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature