Overcoming the Potential Window-Limited Functional Group Compatibility by Alternating Current Electrolysis.

ABSTRACT: The functional group compatibility of an electrosynthetic method is typically limited by its potential reaction window. Here, we report that alternating current (AC) electrolysis can overcome such potential window-limited functional group compatibility. Using alkene heterodifunctionalization as a model system, we design and demonstrate a series of AC-driven reactions that add two functional groups sequentially and separately under the cathodic and anodic pulses, including chloro- and bromotrilfuoromethylation as well as chlorosulfonylation. We discovered that the oscillating redox environment during AC electrolysis allows the regeneration of the redox-active functional groups after their oxidation or reduction in the preceding step. As a result, even though redox labile functional groups s

SUBMITTER: Rodrigo S 

PROVIDER: S-EPMC10774024 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature