ARHGEF16 expression correlates with proliferation, migration and invasion of colon cancer cells.

ABSTRACT:

Background

Rho guanine nucleotide exchange factor 16 (ARHGEF16) is a newly discovered Rho-family guanine nucleotide exchange factor (GEF) involved in the activation of Rho-family GTPases. However, its roles in colon cancer cell proliferation, migration, and invasion remain unknown. This study analyzed the expression of ARHGEF16 in colon cancer and explored its biological effects on colon cancer cells, so as to find new therapeutic targets for the treatment of colon cancer.

Methods

The expression of ARHGEF16 in colon cancer tissues and cells was detected by bioinformatics analysis, western blot, and quantitative real time polymerase chain reaction (qRT-PCR) assays. The effects of overexpression and silencing of ARHGEF16 on the biological behavior of colon cancer cells were ex

SUBMITTER: Liu M 

PROVIDER: S-EPMC10774027 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature