KLRB1 is a novel prognostic biomarker in endometrial cancer and is associated with immune infiltration.

ABSTRACT:

Background

Endometrial cancer (EC) has the characteristics of high mortality and poor prognosis in the advanced stage, which seriously threatens women's health. Killer cell lectin-like receptor B1 (KLRB1) is a promising immune checkpoint of which the expression level can regulate the killing effect on tumor cells of the immune system, thereby affecting the survival and prognosis of tumor patients. However, it is still unclear whether KLRB1 is associated with survival and prognosis in patients with EC. Therefore, our study focused on the relationship between KLRB1 and immune cells to explore the role of KLRB1 on the immune microenvironment, and to further explore its feasibility as a prognostic marker in EC.

Methods

In this study, The Cancer Genome

SUBMITTER: Liang C 

PROVIDER: S-EPMC10774036 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature